Endocrine Abstracts

Medullary thyroid carcinoma (MTC) is a rare thyroid C cell malignant tumor that accounts for 3-4% of thyroid gland neoplasias. MTC may occur sporadically or be inherited. Hereditary MTC appears as part of the MEN 2 syndrome. Germ-line mutations of the RET proto-oncogene cause hereditary cancer, whereas somatic mutations are frequently present in sporadic disease. Currently, early MTC diagnosis followed by total thyroidectomy offers the only possibility of the cure of the disea...

Context: Risk stratification for persistent disease is an important step in pediatric differentiated thyroid cancer (DTC) management. The dynamic risk stratification (DRS) is a well validated system for adults, but not yet for children and adolescents.Objective: To evaluate DRS performance and other prognostic factors in pediatric DTC.Design: Cohort study.Setting: Four DTC referral centers at tertiary teachin...